منابع مشابه
Manipulating megakaryocytes to manufacture platelets ex vivo
Historically, platelet transfusion has proven a reliable way to treat patients suffering from thrombocytopenia or similar ailments. An undersupply of donors, however, has demanded alternative platelet sources. Scientists have therefore sought to recapitulate the biological events that convert hematopoietic stem cells into platelets in the laboratory. Such platelets have shown good function and ...
متن کاملComparative analysis of human ex vivo-generated platelets vs. megakaryocyte- generated platelets in mice: A cautionary tale Authorship
The Children’s Hospital of Philadelphia, Department of Pediatrics, Division of Hematology. 2 Department of Transplantation, Jagiellonian University, Medical College, Cracow, Poland 3 Perelman School of Medicine at the University of Pennsylvania, Departments of Pediatrics and Pathology, Philadelphia PA. 4 The Children’s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine. 5...
متن کاملEx vivo apoptotic and autophagic influence of an estradiol analogue on platelets
BACKGROUND Platelets are known contributors to the vascularization, metastasis and growth of tumors. Upon their interaction with cancer cells they are activated resulting in degranulation and release of constituents. Since the apoptotic- and autophagic effects of 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16) has been shown to occur in vitro and this compound was designed to bind to...
متن کاملHonokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies
Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activity of honokiol in platelet activation are relatively lacking. In the present ...
متن کاملEx vivo DNA Assembly
Even with decreasing DNA synthesis costs there remains a need for inexpensive, rapid, and reliable methods for assembling synthetic DNA into larger constructs or combinatorial libraries. Advances in cloning techniques have resulted in powerful in vitro and in vivo assembly of DNA. However, monetary and time costs have limited these approaches. Here, we report an ex vivo DNA assembly method that...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-121116